Depigmentation can be considered as the best choice for the people with dark skin and those who have large areas of affected skin. The main goal of procedure is to make the whole body colour the same. Drugs such as monobenzylether of hydroquinone are applied to pigment the unaffected areas of the body. Depigmentation procedures are attempted in only a few selected patients. Before starting the treatment, it is necessary to make the patient aware of the factors such as treatment time, course, side effects etc. It may take one or two years for complete Depigmentation.